GC–MS profiling, phytochemical and biological investigation of aerial parts of Leucophyllum frutescens (Berl.) I.M. Johnst. (Cenizo)

Leucophyllum frutescens (Berl.) I.M. Johnst has been used as a crude drug for treating various respiratory ailments, dysentery, cataract and liver disorders in the folk medicine systems by inhabitants of America Mexico. The Phytochemical biological investigation was established spectrophotometrically chemical profiling performed GC–MS analysis. analysis revealed that HELE majorly contains 9-octadecenoic acid (Z)-, methyl ester, pentadecanoic acid, 14-methyl-, 2,6-bis(3,4-methylenedioxyphenyl)-3,7-dioxabicyclooctane, (+)-sesamin, 9,12-octadecadienoic 9,12,15-octadecatrienoic ethyl (Z,Z,Z)-, n-hexadecanoic hexadecanoic phytol, stearate, cyclohexanone, 1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxy phenyl)tetrahydro-, [1R-(1.alpha.,3a.alpha.,4.alpha.,6a.alpha.)]-, squalene. Strong inhibition α-glucosidase urease enzymes observed (IC 50 0.3321 mg.mL −1 ) CHLE 4.711 extracts, respectively. quantification high TPC BULE (189.369±1.393 mg GA.Eq.gm DE ± S.D) TFC (232.458±1.589 Qu.Eq.gm S.D). presented with highest antioxidant content equivalent to Trolox, five different spectrophotometric methods such TAA, DPPH, TEAC, FRAP, CUPRAC. study concludes L. possesses significant antioxidant, antidiabetic cytotoxic activities indicating potential candidate discovery novel phytochemical products industrial applications. • An extensive literature survey information about antioxidants, vitro enzyme assays, metabolomics solvent extracts (aerial) is not available. For first time, were secured evaluated their polyphenolic contents, activities, assays particularly antidiabetic, GC-–MS profiling. can be pharmacognostic tool identification known compounds present HELE. provides scientific evidence strong antioxidants effects, so former fraction effects latter diabetes. Furthermore, isolation specific bioactive discover molecules.